Genetic variation and human disease : principles and evolutionary approaches /

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Main Author: Weiss, Kenneth M.
Format: Book
Published:Cambridge ; New York : Cambridge University Press, c1993.
Series:Cambridge studies in biological anthropology
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Weiss provides a comprehensive yet readable account of concepts and methods new to genetic epidemiology and molecular biology, which allows examination of the genetic basis of biological traits. With human disease as a focus, Weiss illustrates how quantification of genetic variation allows a better understanding of the relationship between genes and phenotype. The first two parts include in-depth background information on genes and their expression, the basic methods of genetic epidemiology, and an explanation of the methods for segregation analysis and linkage mapping for human family traits. Part 3 examines the ways in which evolutionary forces give rise to genetic factors that produce variation in human biological traits. Weiss illustrates how evolution generates heterogeneity, leading to what he calls the "Rusty Rule" (whatever can go wrong will go wrong--in some families, at some time), which ultimately may complicate the application of segregation and linkage analysis to certain biological traits. Part 4 looks at how the inherited genotype may be altered due to various environmental or other biological mechanisms. Weiss does not provide a survey of medical genetics; rather, he chooses specific examples to illustrate his points. Readers need solid statistical knowledge. Extensive bibliography. For collections in biological anthropology, the biological and biomedical sciences, and epidemiology. Advanced undergraduate through professional. N. Krusko; Beloit College

Copyright American Library Association, used with permission.

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