Principles of molecular oncology /

" ... provides a bold new look at the evolution of our knowledge of cancer ... will prove both informative and intellectually satisfying."--E. Donnall Thomas, MD " ... [an] excellent book ... -- Professor Sir David J. Weatherall, FRS, Regius Professor of Medicine, University of Oxford...

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Other Authors: Bronchud, Miguel H.
Format: Book Electronic
Language:English
Published:Totowa, N.J. : Humana Press, ©2000.
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Online Access:SpringerLink - Full text online 
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Uniform Title:Principles of molecular oncology /
Summary:" ... provides a bold new look at the evolution of our knowledge of cancer ... will prove both informative and intellectually satisfying."--E. Donnall Thomas, MD " ... [an] excellent book ... -- Professor Sir David J. Weatherall, FRS, Regius Professor of Medicine, University of Oxford In Principles of Molecular Oncology, award winning basic scientists and clinical researchers summarize the wealth of new molecular knowledge that sees cancer as a "disease process" involving key regulatory pathways. Emphasizing prevention, early diagnosis, prognosis, and treatment, these authoritative experts from around the world illuminate the variety of molecular markers to be found, interpret what is known about diseased regulatory pathways, and examine those future research directions likely to realize the promise of molecular therapy. From their presentations, readers will gain an understanding of why current therapies work or fail, and of the new processes now available to identify specific molecular targets for optimal therapeutic efficacy. Rational therapies designed to target metastatic progression are also critically reviewed. Comprehensive and pathbreaking, Principles of Molecular Oncology offers both basic and clinical oncologists not only a bold synthesis of the rapid and complex advances in molecular biology that are transforming our knowledge of cancer, but also a highly practical guide to today's best strategies for its diagnosis and treatment.

At the midpoint of the 20th century, our knowledge of cancer was based on epide- ology and pathology, and treatment consisted of surgery and radiation therapy. At mid-century, Medawar and colleagues initiated the understanding of transplantation immunology, Farber described the first use of an antifolic drug to treat leukemia, and Jacobson and coworkers described the irradiation-protection effect of spleen cells. These observations opened the door to the development of chemotherapy and tra- plantation in the treatment of cancer. Despite the rapid development of these new disciplines, progress was usually based on empiric observations and clinical trials. The rapid advances in molecular biology at the end of the 20th century mark a new era in our knowledge of cancer. Molecular immunology, molecular genetics, mole- lar pharmacology, and the Human Genome Project are in the process of providing a level of understanding of cancer undreamed of in the past. Optimism is based on the firm belief that understanding at the molecular level will lead to better and earlier di- nosis, to new forms of treatment, and, most importantly, eventually to prevention of many types of cancer.

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Physical Description:1 online resource (xvi, 452 pages) : illustrations
System Details:Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Bibliography:Includes bibliographical references and index.
ISBN:1592592228 (electronic bk.)
9781592592227 (electronic bk.)
Restrictions:Restrictions unspecified